Learning Molecular Representations for Medicinal Chemistry
نویسندگان
چکیده
منابع مشابه
Molecular Medicinal Chemistry IDECEFYN
Several lymphoma T cell lines differ in membrane superficial markers and do not respond to the same drugs and compounds. Tilia x viridis (Bayer) Simonk nothosubspecie moltkei (Dippel) Xifreda is a plant widely distributed in Argentina. The aim of this work was to study comparatively the effects of dichloromethane extract and isolated compounds on BW 5147 and on another T lymphoma cell line EL-4...
متن کاملMolecular Shape and Medicinal Chemistry: A Perspective
The eight contributions here provide ample evidence that shape as a volume or as a surface is a vibrant and useful concept when applied to drug discovery. It provides a reliable scaffold for "decoration" with chemical intuition (or bias) for virtual screening and lead optimization but also has its unadorned uses, as in library design, ligand fitting, pose prediction, or active site description....
متن کاملMedicinal chemistry and molecular pharmacology of GABA(C) receptors.
GABA(C) receptors belong to the nicotinicoid superfamily of ionotropic receptors that include nicotinic acetylcholine receptors, bicuculline-sensitive GABA(A) receptors, strychnine-sensitive glycine receptors and 5HT3 serotonin receptors. The GABA(C) receptor concept arose from medicinal chemical studies of a conformationally restricted analog of GABA. Receptors matching the predicted propertie...
متن کاملTeam-Based Learning Applied to a Medicinal Chemistry Course
itly stated what factual material needed to be learned prior to the class session. This course met for a 2-hour session, once a week. At the beginning of each session, the students took a 10-question quiz that tested the recall and understanding of the factual information in the reading assignment. The weekly quiz motivated each student to come prepared. At the end of the quiz, the students han...
متن کاملFluorine in medicinal chemistry.
Since its first use in the steroid field in the late 1950s, the use of fluorine in medicinal chemistry has become commonplace, with the small electronegative fluorine atom being a key part of the medicinal chemist's repertoire of substitutions used to modulate all aspects of molecular properties including potency, physical chemistry and pharmacokinetics. This review will highlight the special n...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Medicinal Chemistry
سال: 2020
ISSN: 0022-2623,1520-4804
DOI: 10.1021/acs.jmedchem.0c00385